Phenylpropanoids and polyketides
Medchemexpress LLC (-)-Epicatechin gallate (Standard) | 1257-08-5 | 97.7% | 442.37 | 50 MG
(-)-Epicatechin gallate (Standard) is the analytical standard of (-)-Epicatechin gallate. This product is intended for research and analytical applications. It inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. It is also a GLUT1 and GLUT5 inhibitor, and decreases cell growth of GLUT5-expressing hxt0 yeast cells.
- Analytical standard for (-)-Epicatechin gallate.
- Intended for research and analytical applications.
- Inhibits cyclooxygenase-1 (COX-1).
- Acts as a GLUT1 and GLUT5 inhibitor.
- Decreases cell growth of GLUT5-expressing hxt0 yeast cells.
- Commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Medchemexpress LLC Apigenin-7-O-(2G-rhamnosyl)gentiobioside | 174284-20-9 | 1 MG
Apigenin-7-O-(2G-rhamnosyl)gentiobioside is a flavone glycoside found in *Lonicera gracilipes* var. *glandulosa*. It has a molecular weight of 740.66 and a molecular formula of C33H40O19. This product is intended for research use only.
- Solid appearance
- Store at 4°C, protected from light
- Soluble in DMSO at 50 mg/mL
Medchemexpress LLC Luteolin-3-O-beta-D-glucuronide | 53527-42-7 | 25 MG
Luteolin-3-O-beta-D-glucuronide is a flavonoid compound and a metabolite of Luteolin. It is present in Rosmarinus officinalis L. and is for research use only.
- High purity: 99.02%
- Appears as a light yellow to yellow solid
- Classified as a flavonoid compound and metabolite
- Derived from Rosmarinus officinalis L.
Cayman Chemical Apigenin Inhibitors
Inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM; potent inhibitor of NO and PGE2 biosynthesis by reducing iNOS and COX-2 expression
Apexbio Technology LLC Luteolin 491-70-3 10mM (in 1mL DMSO)
Luteolin (CAS 491-70-3) is a naturally occurring flavonoid characterized by anti-inflammatory antioxidant and chemopreventive properties Mechanistically it suppresses lipopolysaccharide (LPS)-mediated inflammation by inhibiting production of pro-inflammatory cytokines such as TNF- and IL-6 reducing inducible nitric oxide synthesis and blocking NF- B and AP-1 signaling pathways Additionally luteolin impedes TNF- -induced cyclooxygenase-2 (COX-2) expression In preclinical in vivo studies it exhibits antiproliferative activity against tumor cell proliferation exemplified by growth inhibition in Lewis lung carcinoma models Consequently luteolin is widely investigated in biomedical research targeting inflammation oxidative stress and cancer biology
Medchemexpress LLC Apigenin (Standard) | 520-36-5 | 270.24 | 25 MG
Apigenin (Standard) is the analytical standard of Apigenin, intended for research and analytical applications. It is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Reference standard supplied assay
- For research use only
Cayman Chemical EpIcatechIn Galate 10mg
A natural catechin which inhibits the growth of cancer cells and has anti-inflammatory effects; has potent antioxidant activity and facilitates the killing of methicillin-resistant strains of S. aureus
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 25 MG
Luteolin 7-O-glucuronide is an inhibitor of Matrix Metalloproteinases (MMP) activities. It is a solid, white to light yellow in color, and is intended for research use only. This compound inhibits NO production and mRNA expression of various inflammatory mediators in LPS-stimulated RAW 264.7 macrophages.
- Inhibits matrix metalloproteinases (MMP) activities
- Inhibits NO production and mRNA expression of inflammatory mediators
- Improves depression-like and stress coping behaviors in mouse models
- Available as a white to light yellow solid
- For research use only
Apexbio Technology LLC (-)-epicatechin 490-46-0 10mg
(-)-Epicatechin (CAS 490-46-0) is a flavonoid compound known for inducing pancreatic -cell regeneration and modulating nitric oxide (NO) metabolism It inhibits nitric oxide-related nitrite formation induced by interferon- and lipopolysaccharide in mouse macrophages and reduces peroxynitrite-mediated tyrosine nitration in HL-60 human leukemia cells Additionally in human endothelial cells (HUVECs) it enhances NO production displaying vasodilatory properties In diabetic rat models (alloxan-induced) (-)-epicatechin administration promotes -cell recovery reduces hyperglycemia and prevents -cell necrosis This profile underscores its research relevance for diabetes and vascular biology investigations
Medchemexpress LLC Apigenin (4',5,7-Trihydroxyflavone) | 520-36-5 | HY-N1201 | 98.9% | 270.24 | 500 MG
Apigenin (4',5,7-Trihydroxyflavone) is identified as a competitive CYP2C9 inhibitor with a Ki of 2 μM. It demonstrates the ability to inhibit cell proliferation, with growth inhibition rates of 38%, 71%, and 99% at concentrations of 20, 40, and 80 μM respectively. The compound also suppresses clone formation in SGC-7901 cells in a dose- and time-dependent manner.
- Competitive inhibitor of Cytochrome P450 2C9 (CYP2C9).
- Exhibits cell proliferation inhibitory activity.
- Suppresses clone formation in specific cell lines.
Sigma Aldrich Fine Chemicals Biosciences Luteolin 98 TLC powder50MG
Luteolin (3AE 4AE 5AE 7AE-tetrahydroxyflavone) a polyphenolic compound belongs to flavones subclass of flavonoids. Luteolin is commonly found in plants like celery green peppers and chamomile tea. Luteolin is one of the major flavonoids present in the flower extract of Hieracium pannosum Boiss aerial part of Dracocephalum kotschyi and contributes to the antioxidant potential of the plant. Luteolin possesses antioxidant anti-inflammatory properties and exerts anti-tumor potential primarily through apoptosis. Luteolin exerts its apoptotic activity through downregulation of protein kinase B (Akt) pathway leading to caspase mediated apoptosis. Luteolin also resensitizes cancer cells to therapeutics. Luteolin regulates the inflammatory genes and reduces nitric oxide and inflammatory cytokine production. The anti-inflammatory property of luteolin implicates it as a potential therapeutic agent for the neurodegenerative disease like Alzheimer disease. In plants luteolin induces nodu
Medchemexpress LLC Apigenin | 520-36-5 | 270.24 | 1 G
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor that inhibits cytochrome P450 2C9 in a purified enzyme system. It demonstrates dose- and time-dependent inhibition of cell proliferation in SGC-7901 cells.
- Competitive CYP2C9 inhibitor with a Ki of 2 μM.
- Inhibits cytochrome P450 2C9 in a purified, reconstituted enzyme system.
- Demonstrates inhibition of cell proliferation in SGC-7901 cells in a dose- and time-dependent manner.
- Achieves growth inhibition rates of 38%, 71%, and 99% at 20, 40, and 80 μM, respectively, on the 7th day.
- Cloning efficiency in SGC-7901 cells treated with 80 μM for 24 and 48 hours was 9.8% and 5%, respectively.
Apexbio Technology LLC (-)-epicatechin gallate 1257-08-5 20mg
(-)-Epicatechin gallate (ECG) is a catechin compound abundant in green tea displaying bioactivity to modulate cell proliferation apoptosis and gene expression pathways In colon HCT-116 cells ECG induces apoptosis through activating transcription factor 3 (ATF3) regulated via activation of early growth response protein 1 (EGR-1) In these cancer cells ECG upregulates apoptotic factor NAG-1 and increases caspase-3 activity at concentrations around 150 M ECG s cytotoxic potency differs among cell types with an NR50 (midpoint cytotoxic concentration) of approximately 67 M in HSC-2 oral cancer cells while normal human fibroblast HGF-2 cells show greater resistance with an NR50 near 100 M ECG metabolites identified in rat urine include various O-methylated derivatives useful as biomarkers for metabolism studies ECG serves as a research tool for oncology mechanisms and apoptosis signaling pathways
TARGETMOL CHEMICALS INC Apigenin 200MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing qualities as a sedative, mild analgesic and sleep medication. Apigenin has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. Purity 99.66%
Medchemexpress LLC Apigenin-7-glucuronide | 29741-09-1 | 446.36 | 1 MG
Apigenin-7-glucuronide is a compound that inhibits Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, and 0.27 μM for MMP-3, MMP-8, MMP-9, and MMP-13, respectively. This product is for research use only.
- Inhibits matrix metalloproteinases (MMPs)
- Effective against MMP-3, MMP-8, MMP-9, and MMP-13
- Soluble in DMSO up to 250 mg/mL